Sleep: A Non-REM Sleep Assist Enhanced with Nanotechnology
Whether you’re 8 months old or 85 years old, sleep will always be a vital part of your well-being.
For infants and toddlers, sleep plays an important role in overall development, including cognition, physical growth, and building strong defenses.
As we age and reach our teen years, sleep supports the high-demand changes our bodies undergo. As adults and seniors, we experience high stress and continued changes that require our bodies to rest and reset.
Every facet of your mental, emotional, or physical development is affected by sleep throughout the entirety of your life.
Unfortunately, studies show we don’t get the quantity or quality of sleep we need to support the well-being of our bodies. For example, the Centers for Disease Control and Prevention (CDC) reports that 58% of middle schoolers and 72% of high school students get less than the recommended amount of sleep [1]. Additionally, a different study reported that 30% of the population suffers from insomnia [2].
Getting a good night's sleep is not only about the quantity of the hours we sleep but also the quality: It's about ensuring the body experiences a balanced interplay between sleep stages to help its functions and processes rest and reset the way they need to. When we deprive our bodies of this short term, it tends to interfere with our social functioning, alertness, and thinking ability. However, as sleep deprivation becomes a long-term issue, it begins to affect the body in more severe ways, such as immunodeficiency, mental health disorders, chronic fatigue, hormone imbalances, obesity, pain, diabetes, and cardiovascular diseases [3].
Although there are countless sleep supplements on the market that aim to help with sleep deprivation, Solex saw the opportunity to develop a sleep assist supplement, unlike anything already available; something that has high-quality ingredients, supports the main pillars of natural sleep, and doesn't add stress on the body.
Sleep by Solex invites the body to go through the entire sleep process naturally. Using nanotechnology to enhance the absorption and purpose of each ingredient in its combination, Solex has developed a one-of-a-kind sleep supplement unlike any other.
Sleep Benefits
Sleep by Solex promotes a balanced interplay between sleep stages to stimulate good-quality sleep that can support overall health. Sleep targets the three pillars that help your body recover and recharge to perform optimally.
Neurological calming - When we sleep, the brain resets itself, removing toxic waste byproducts that accumulate throughout the day. The ingredients used in Sleep help the brain calm down to a state where it can execute maintenance functions and restore energy [4].
Muscular calming - Stress and pain are strongly connected to an increased risk of poor sleep. Sleep uses high-quality ingredients to help your muscles relax naturally and achieve a state of calmness that can help you sleep faster and better [5].
Liver support - The liver is vital for detoxifying and destroying substances that are harmful to the body. When we sleep, the liver works its hardest to cleanse and detoxify our bodies between 1 and 3 am. The ingredients in Sleep help the liver naturally perform regulatory processes efficiently and non-disruptively [6].
Ingredients in Sleep
The ingredients in Sleep maximize the use of each material while working synergistically without causing added stress to the body. Solex's Sleep works as a sleep aid to help your body naturally rest and support profound sleep.
Phenyl-GABA or Pharma GABA (gamma-aminobutyric acid)
GABA is produced in the brain but can also be consumed as a dietary supplement. It works as a neurotransmitter to facilitate communication between brain cells, with its central role in reducing the activity of neurons in the brain and the central nervous system. GABA allows for increased relaxation, creating a calming effect, reducing stress, relieving anxiety, enhancing relaxation, and improving sleep [7, 8].
Magnesium Glycinate (or Mag non-buffered Biglycinate Chelate)
Magnesium Glycinate is a combination of elemental magnesium with the amino acid glycine. Unlike other types of magnesium available in the market, Magnesium Glycinate is easily absorbed. Glycinate has been found to improve sleep by reducing core body temperature and has additional benefits such as regulating blood pressure, blood sugar levels, and muscle and nerve functions [9, 10, 11, 12].
Taurine
Taurine is also a naturally occurring sulfur-containing amino acid. It acts as a GABA receptor agonist, a receptor in a brain region known to help calm brain activity, reduce anxiety, and regulate sleep. Taurine also creates melatonin in the pineal gland to signal the brain when it should be feeling sleepy {13, 14, 15, 16].
Glycine
Glycine is an amino acid commonly used to produce glutathione (a powerful antioxidant). Because of its ability to be both excitatory and inhibitory for the brain and nervous system, it plays a vital role in cognition, mood, appetite, and sleep. To support sleep, it has a calming effect on the brain, lowers your core body temperature, reduces insomnia symptoms, and elevates serotonin [17, 18].
L-Theanine
L-Theanine is a form of Theanine, a naturally occurring amino acid. It has a neuroprotective effect by suppressing the extracellular release of glutamate by inhibiting the glutamine transporter. L-Theanine is said to have the opposite effect of caffeine, acting like a depressant of neural activity and mitigating physiological and felt-stress responses.
L-Theanine promotes relaxation without drowsiness; it is not a sedative but a promoter of good-quality sleep through anxiolysis. Additionally, it affects GABA, dopamine, and serotonin levels while decreasing norepinephrine. These chemical changes slow brain activity and are linked to reducing stress and anxiety [19, 20, 21].
Melatonin
Melatonin is a hormone produced in the brain that regulates cycles of sleep and wakefulness. Melatonin is available as a dietary supplement in appropriate amounts, especially since its production in the body declines with age. It helps with the timing of the circadian rhythm and sleep [22, 23].
Magnesium Citrate
Magnesium Citrate is an ionic compound with positively charged magnesium and negatively charged citrate ions used in every body tissue. The nerves' and muscles' signal transmissions are critical to their role in Sleep by Solex. Magnesium Citrate impacts chemicals in the brain, such as GABA, melatonin, renin, and cortisol, which promote relaxation and sleep and affect how tired the body feels [24, 25, 26, 27].
Milk Thistle Extract
Milk Thistle Extract derives from the milk thistle plant, Silybum marianum. For centuries, it has been used as an herbal remedy for liver health, protecting it against toxins and decreasing inflammation [28, 29, 30, 31, 32}.
Chamomile Flower Oil (German)
Chamomile is a gentle herb in traditional medicine used for thousands of years to promote relaxation and sleep [33, 34].
Serving Size Recommendation
Dosage: 1ml (approximately 5 sprays) per serving
30 servings in a bottle
Variance can happen from person to person; adjust the serving size according to your needs. (Some people may need only one spray to achieve desired results; others may need 6 or 7).
Nanotechnology in Sleep
Wondering why Sleep has lower dosages of ingredients than the average sleep aid in capsule or powder form?
The secret is in Nanotechnology.
Nano Technology separates the binding of molecular structures into smaller and smaller sizes to allow for more effective and efficient absorption. When this happens with the molecular structures we consume in our supplements, they become bioavailable at the cellular level, improving the reach of the ingredients without adding stress to the body.
Nanosizing benefits in Sleep:
Enhanced absorption
Less waste
Lower biological stress
Lower energy lost
Science and FAQs
-
Q: What makes Sleep unique?
A: Sleep is the first and only innovative product formulated with liquid nanotechnology for enhanced absorption, biotuned, calming mindfulness, muscular relaxing and restoration, liver support and detox, allowing you to gently fall into deep restorative sleep and wake up feeling invigorated and full of energy.
Q: Can I take Sleep daily?
A: Yes, Sleep contains nanotechnology which allows a potent lower dose that will not cause dependency or grogginess.
Q: What are the active ingredients in Sleep?
A: Phenyl-GABA (gamma-aminobutyric acid), magnesium glycinate and citrate, taurine, glycine, L-Theanine, melatonin, milk thistle, chamomile flower oil. This unmatched liquid nano restorative sleep combination is formulated to help your body recover and recharge each night.
Q: Is it okay to take other supplements along with Sleep?
A: Take each of our supplements as directed on the label and avoid taking other branded herbal remedies and medicinal therapies with Sleep that may make you feel drowsy or sleepy.
Q: Is it safe for kids to take Sleep?
A: If you are under the age of 18, this product should be taken under the supervision of an adult. All the ingredients in Sleep are safe for children over the age of 4 years old to take under the guidance of a parent.
Q: If I suffer from a medical condition, can I take Sleep?
A: If you are under the care of a licensed practitioner for any condition, please consult with them before taking any dietary supplement and/or sleep remedy.
Q: When is the best time to take Sleep, and how much should I take?
A: Take Sleep within 2 hours before going to bed. Spray five pumps directly in your mouth. Variance can happen from person to person; adjust the serving size according to your needs. (Some may need only 2-3 sprays; others may need more to achieve the desired result).
Q: Are the ingredients clinically proven to work?
A: There are numerous clinical studies for each ingredient in the Sleep formula that have demonstrated improved restorative sleep. Please refer to the ‘References’ section of this blog to find some of the studies perform on the Ingredients in Sleep.
Q: Are there any adverse reactions or side effects?
A: There are no known adverse reactions or side effects from the nutrients in Sleep. If you are under the age of 18, pregnant, or have a pre-existing medical condition, consult with your healthcare provider before taking this product. Discontinue use if you suspect any adverse reaction does occur.
Q: Why is Sleep in spray form?
A: The fine spray is to mist the mouth with the nano ingredients in Sleep. This misting will assist in spreading the benefits over the surface of the mouth and tongue to have the fastest absorption.
Q: How does the pump on the bottle work?
A: The pump must be "primed" for initial use (getting fluid into the straw) for the fine spray pump used for Sleep.
When needed, reset the pump by pulling the pump to full extension to repeat full sprays. Additionally, it's important to shake the bottle well before pumping so particles remain suspended evenly throughout the bottle.
-
Wheaton, Anne B., et al. “Short Sleep Duration among Middle School and High School Students - United States, 2015.” Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, 25 Jan. 2018, www.cdc.gov/mmwr/volumes/67/wr/mm6703a1.htm?s_cid=mm6703a1_w.
Bannai, Makoto et al. “The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers.” Frontiers in neurology vol. 3 61. 18 Apr. 2012, doi:10.3389/fneur.2012.00061 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328957/
“What Are Sleep Deprivation and Deficiency?” National Heart Lung and Blood Institute, U.S. Department of Health and Human Services, 24 Mar. 2022, https://www.nhlbi.nih.gov/health/sleep-deprivation#:~:text=Sleep%20deficiency%20can%20interfere%20with,or%20worried%20in%20social%20situations.
Eugene, Andy R, and Jolanta Masiak. “The Neuroprotective Aspects of Sleep.” MEDtube science vol. 3,1 (2015): 35-40. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651462/
Bannai, Makoto et al. “The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers.” Frontiers in neurology vol. 3 61. 18 Apr. 2012, doi:10.3389/fneur.2012.00061 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258880/
Ferrell, Jessica M, and John Y L Chiang. “Circadian rhythms in liver metabolism and disease.” Acta pharmaceutical Sinica. B vol. 5,2 (2015): 113-22. doi: 10.1016/j.apsb.2015.01.003 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629216/
Professional, Cleveland Clinic medical. “Gamma-Aminobutyric Acid (GABA): What It Is, Function & Benefits.” Cleveland Clinic, my.clevelandclinic.org/health/articles/22857-gamma-aminobutyric-acid-gaba.
Hepsomali, Piril et al. “Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review.” Frontiers in neuroscience vol. 14 923. 17 Sep. 2020, doi:10.3389/fnins.2020.00923 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527439/
“Bioavailability of Magnesium Di-glycinate vs Magnesium Oxide In ...” Aspen Journals, The American Society for Parenteral and Enteral Nutrition, aspenjournals.onlinelibrary.wiley.com/doi/abs/10.1177/0148607194018005430.
Andrew. “Magnesium Bisglycinate (Glycinate) - What You Need to Know.” 88Herbs, 26 Jan. 2023, https://88herbs.com/magnesium-bisglycinate/
Bannai, Makoto et al. “The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers.” Frontiers in neurology vol. 3 61. 18 Apr. 2012, doi:10.3389/fneur.2012.00061. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328957/
“Magnesium Glycinate: Benefits, Side Effects, Dosage, and More.” Medical News Today, Medi Lexicon International, https://www.medicalnewstoday.com/articles/315372#benefits
Walle, Gavin Van De. “What Is Taurine? Benefits, Side Effects, and More.” Healthline, Healthline Media, 28 Feb. 2023, https://www.healthline.com/nutrition/what-is-taurine
Lin, Fang Ju et al. “Effect of taurine and caffeine on sleep-wake activity in Drosophila melanogaster.” Nature and science of sleep vol. 2 221-31. 24 Sep. 2010, doi:10.2147/NSS.S13034 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630960/#:~:text=Our%20data%20support%20our%20hypothesis,that%20mediate%20caffeine%2Dinduced%20arousal
Jong, Chian Ju et al. “The Role of Taurine in Mitochondria Health: More Than Just an Antioxidant.” Molecules (Basel, Switzerland) vol. 26,16 4913. 13 Aug. 2021, doi:10.3390/molecules26164913 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400259/
Wheler GH, Weller JL, Klein DC. Taurine: stimulation of pineal N-acetyltransferase activity and melatonin production via a beta-adrenergic mechanism. Brain Res. 1979 Apr 20;166(1):65-74. doi: 10.1016/0006-8993(79)90650-4. PMID: 217502. https://pubmed.ncbi.nlm.nih.gov/217502/#:~:text=Taurine%3A%20stimulation%20of%20pineal%20N,via%20a%20beta%2Dadrenergic%20mechanism
Kawai N, Sakai N, Okuro M, Karakawa S, Tsuneyoshi Y, Kawasaki N, Takeda T, Bannai M, Nishino S. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology. 2015 May;40(6):1405-16. doi: 10.1038/npp.2014.326. E-pub 2014 Dec 23. PMID: 25533534; PMCID: PMC4397399. https://pubmed.ncbi.nlm.nih.gov/25533534/
Bannai M, Kawai N. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep. J Pharmacology Sci. 2012;118(2):145-8. doi: 10.1254/jphs.11r04fm. Pub 2012 Jan 27. PMID: 22293292. https://pubmed.ncbi.nlm.nih.gov/22293292/
Baba, Yoshitake et al. “Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.” Journal of medicinal food vol. 24,4 (2021): 333-341. doi:10.1089/jmf.2020.4803 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080935/#:~:text=l%2Dtheanine%20(%CE%B3%2Dglutamylethylamide,theanine%20is%20effective%20are%20unclear
Giles GE, Mahoney CR, Brunyé TT, Taylor HA, Kanarek RB. Caffeine and theanine exert opposite effects on attention under emotional arousal. Can J Physiol Pharmacol. 2017 Jan;95(1):93-100. doi: 10.1139/cjpp-2016-0498. PMID: 28044450. https://pubmed.ncbi.nlm.nih.gov/28044450/#:~:text=L%2Dtheanine%20in%20tea%20may,physiological%20and%20felt%20stress%20responses
Rao, Theertham P et al. “In Search of a Safe Natural Sleep Aid.” Journal of the American College of Nutrition vol. 34,5 (2015): 436-47. doi:10.1080/07315724.2014.926153 https://pubmed.ncbi.nlm.nih.gov/25759004/#:~:text=L%2DTheanine%20promotes%20relaxation%20without,a%20safe%20natural%20sleep%20aid
"Melatonin: What You Need To Know." National Center for Complementary and Integrative Health (NCCIH), 1 Jul. 2022, https://www.nccih.nih.gov/health/melatonin-what-you-need-to-know
"Melatonin." Mayo Clinic, 10 Aug. 2023, www.mayoclinic.org/drugs-supplements-melatonin/art-20363071#:~:text=Your%20body%20likely%20produces%20enough,and%20provide%20some%20insomnia%20relief.
Summer, Jay, and Abhinav Singh. “Using Magnesium for Better Sleep.” Sleep Foundation, 20 Dec. 2023, www.sleepfoundation.org/magnesium.
“Magnesium Citrate: Health Benefits, Nutrients per Serving, Preparation Information, and More.” WebMD, WebMD, 23 Nov. 2023, www.webmd.com/diet/health-benefits-magnesium-citrate.
Mah, Jasmine, and Tyler Pitre. “Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis.” BMC complementary medicine and therapies vol. 21,1 125. 17 Apr. 2021, doi:10.1186/s12906-021-03297-z https://pubmed.ncbi.nlm.nih.gov/33865376/
Boyle, Neil Bernard et al. “The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review.” Nutrients vol. 9,5 429. 26 Apr. 2017, doi:10.3390/nu9050429 https://pubmed.ncbi.nlm.nih.gov/28445426/
Polachi, Navaneethakrishnan et al. “Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer - A comprehensive review.” European journal of medicinal chemistry vol. 123 (2016): 577-595. doi:10.1016/j.ejmech.2016.07.070 https://pubmed.ncbi.nlm.nih.gov/27517806/
Federico, Alessandro et al. “Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years.” Molecules (Basel, Switzerland) vol. 22,2 191. 24 Jan. 2017, doi:10.3390/molecules22020191 https://pubmed.ncbi.nlm.nih.gov/28125040/
Losser MR, Payen D. Mechanisms of liver damage. Semin Liver Dis. 1996 Nov;16(4):357-67. doi: 10.1055/s-2007-1007249. PMID: 9027949. https://pubmed.ncbi.nlm.nih.gov/9027949/
Abenavoli, Ludovico et al. “Milk thistle in liver diseases: past, present, future.” Phytotherapy research : PTR vol. 24,10 (2010): 1423-32. doi:10.1002/ptr.3207 https://pubmed.ncbi.nlm.nih.gov/20564545/
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.